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  • ‘Does calorie restriction increase life span in humans?’ references

    Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.

    Authors and Abstract

    The effect of retarded growth upon the length of life span and upon the ultimate body size.
    McCay CM, Crowell MF, Maynard LA.
    J Nutr. 1935;10:63–79.

    Honoring Clive McCay and 75 Years of Calorie Restriction Research
    Roger B. McDonald3,* and Jon J. Ramsey4
    Departments of 3Nutrition and 4Molecular Biosciences, School of Veterinary Medicine, University of California
    J Nutr. Jul 2010; 140(7): 1205–1210. doi: 10.3945/jn.110.122804 PMCID: PMC2884327

    Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression.
    Cheng CW1, Adams GB2, Perin L3, Wei M1, Zhou X2, Lam BS2, Da Sacco S3, Mirisola M4, Quinn DI5, Dorff TB5, Kopchick JJ6, Longo VD7.
    Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014.

    Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients 
    Lee C Longo VD.

    Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91. Epub 2011 Apr 25.

    Caloric restriction delays disease onset and mortality in rhesus monkeys.
    Colman RJ1, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R.
    Wisconsin National Primate Research Center, University of Wisconsin
    Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.

    Impact of caloric restriction on health and survival in rhesus monkeys: the NIA study
    Julie A. Mattison,1,* George S. Roth,2 T. Mark Beasley,3 Edward M. Tilmont,1 April H. Handy,1,4 Richard L. Herbert,5Dan L. Longo,1 David B. Allison,6 Jennifer E. Young,1 Mark Bryant,7 Dennis Barnard,7 Walter F. Ward,8 Wenbo Qi,9Donald K. Ingram,10 and Rafael de Cabo1,#
    1Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    2GeroScience, Pylesville, MD 21132, USA
    3Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    4SoBran, Inc., Burtonsville, MD 20866, USA
    5National Institute of Allergy and Infectious Disease, NIH, Dickerson, MD 20842, USA
    6Office of Energetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    7Division of Veterinary Resources, NIH, Bethesda MD 20892, USA
    8Department of Physiology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    9Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    10Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    PMCID: PMC3832985 NIHMSID: NIHMS528393

    Caloric Restriction in Humans
    John O. Holloszy1 and Luigi Fontana1,2
    1 Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, Missouri, USA
    2 the Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanitá, Rome, Italy
    Please address correspondence to: John O. Holloszy, MD, Professor of Medicine, Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine
    PMCID: PMC2020845
    Exp Gerontol. Aug 2007; 42(8): 709–712.
    Published online Mar 31, 2007. doi: 10.1016/j.exger.2007.03.009

    Posted in References.

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