Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.
Authors and Abstract
The effect of retarded growth upon the length of life span and upon the ultimate body size.
McCay CM, Crowell MF, Maynard LA.
J Nutr. 1935;10:63–79.
Honoring Clive McCay and 75 Years of Calorie Restriction Research
Roger B. McDonald3,* and Jon J. Ramsey4
Departments of 3Nutrition and 4Molecular Biosciences, School of Veterinary Medicine, University of California
J Nutr. Jul 2010; 140(7): 1205–1210. doi: 10.3945/jn.110.122804 PMCID: PMC2884327
Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression.
Cheng CW1, Adams GB2, Perin L3, Wei M1, Zhou X2, Lam BS2, Da Sacco S3, Mirisola M4, Quinn DI5, Dorff TB5, Kopchick JJ6, Longo VD7.
Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014.
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients
Lee C Longo VD.
Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91. Epub 2011 Apr 25.
Caloric restriction delays disease onset and mortality in rhesus monkeys.
Colman RJ1, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R.
Wisconsin National Primate Research Center, University of Wisconsin
Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.
Impact of caloric restriction on health and survival in rhesus monkeys: the NIA study
Julie A. Mattison,1,* George S. Roth,2 T. Mark Beasley,3 Edward M. Tilmont,1 April H. Handy,1,4 Richard L. Herbert,5Dan L. Longo,1 David B. Allison,6 Jennifer E. Young,1 Mark Bryant,7 Dennis Barnard,7 Walter F. Ward,8 Wenbo Qi,9Donald K. Ingram,10 and Rafael de Cabo1,#
1Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA
2GeroScience, Pylesville, MD 21132, USA
3Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
4SoBran, Inc., Burtonsville, MD 20866, USA
5National Institute of Allergy and Infectious Disease, NIH, Dickerson, MD 20842, USA
6Office of Energetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
7Division of Veterinary Resources, NIH, Bethesda MD 20892, USA
8Department of Physiology, University of Texas Health Science Center at San Antonio, TX 78229, USA
9Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA
10Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
PMCID: PMC3832985 NIHMSID: NIHMS528393
Caloric Restriction in Humans
John O. Holloszy1 and Luigi Fontana1,2
1 Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, Missouri, USA
2 the Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanitá, Rome, Italy
Please address correspondence to: John O. Holloszy, MD, Professor of Medicine, Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine
PMCID: PMC2020845
NIHMSID: NIHMS28274
Exp Gerontol. Aug 2007; 42(8): 709–712.
Published online Mar 31, 2007. doi: 10.1016/j.exger.2007.03.009