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  • Fructose References

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    Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues.

    Authors and Abstract

    Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet.

    Authors and Abstract

    Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.

    Authors and Abstract

    The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial.
    Madero M1, Arriaga JC, Jalal D, Rivard C, McFann K, Pérez-Méndez O, Vázquez A, Ruiz A, Lanaspa MA, Jimenez CR, Johnson RJ, Lozada LG.
    Metabolism. 2011 Nov;60(11):1551-9. doi: 10.1016/j.metabol.2011.04.001. Epub 2011 May 31.

    Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and
    systemic inflammation
    Faizan Jameel, Melinda Phang, Lisa G Wood, Manohar L Garg
    Lipids in Health and Disease 2014, 13:195

    Dietary sugars: a fat difference.
    Hofmann SM, Tschöp MH.
    J Clin Invest. 2009 May;119(5):1089-92.

    Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: The role of insulin resistance.
    Van Name M1, Giannini C, Santoro N, Jastreboff AM, Kubat J, Li F, Kursawe R, Savoye M, Duran E, Dziura J, Sinha R, Sherwin RS, Cline G, Caprio S.
    Yale University School of Medicine
    Obesity (Silver Spring). 2015 Feb 3. doi: 10.1002/oby.21019. [Epub ahead of print]
    Objective:
    This study evaluated the effects of glucose and fructose ingestion on ghrelin and PYY in lean and obese adolescents with differing insulin sensitivity.
    Conclusions:
    Compared with lean, OIS adolescents have impaired acyl-ghrelin responses to fructose but not glucose, whereas OIR adolescents have blunted responses to both. Diminished suppression of acyl-ghrelin in childhood obesity, particularly if accompanied by insulin resistance, may promote hunger and overeating.

    Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women

    Authors and Abstract

    Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways

    Authors and Abstract

    Dietary components in the development of leptin resistance.
    Vasselli JR, Scarpace PJ, Harris RB, Banks WA.
    Adv Nutr. 2013 Mar 1;4(2):164-75. doi: 10.3945/an.112.003152.

    Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies.
    Stanhope KL, Schwarz JM, Havel PJ.
    Curr Opin Lipidol. 2013 Apr 16. [Epub ahead of print]

    Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome.
    Stanhope KL.
    Annu Rev Med. 2012;63:329-43. doi: 10.1146/annurev-med-042010-113026. Epub 2011 Oct 27.

    Pathophysiology of human visceral obesity: an update.
    Tchernof A, Després JP.
    Physiol Rev. 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011.

    Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people.
    Bray GA.
    Adv Nutr. 2013 Mar 1;4(2):220-5. doi: 10.3945/an.112.002816.

    Dietary Fructose and Metabolic Syndrome and Diabetes
    John P. Bantle
    J Nutr. Jun 2009; 139(6): 1263S–1268S.

    Soft drinks consumption and nonalcoholic fatty liver disease
    William Nseir, Fares Nassar, and Nimer Assy
    World J Gastroenterol. 2010 June 7; 16(21): 2579–2588.

    Soft drink consumption and obesity: it is all about fructose
    George A. Bray
    Current Opinion in Lipidology 2010, 21:51–57

    Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
    Chad L. Cox, Kimber L. Stanhope, Jean Marc Schwarz, James L. Graham, Bonnie Hatcher, Steven C. Griffen, Andrew A. Bremer, Lars Berglund, John P. McGahan, Peter J. Havel, Nancy L. Keim
    Eur J Clin Nutr. Author manuscript; available in PMC 2012 August 1.
    Published in final edited form as: Eur J Clin Nutr. 2012 February; 66(2): 201–208. Published online 2011 September 28. doi: 10.1038/ejcn.2011.159

    Fructose consumption: Recent results and their potential implications
    Kimber L. Stanhope1,2 and Peter J. Havel1,2
    Ann N Y Acad Sci. Author manuscript; available in PMC 2011 April 13.
    Published in final edited form as: Ann N Y Acad Sci. 2010 March; 1190: 15–24. doi: 10.1111/j.1749-6632.2009.05266.x

    Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans.
    Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ.
    Nutr Metab (Lond). 2012 Jul 24;9(1):68. doi: 10.1186/1743-7075-9-68.

    Uric Acid, Hyperuricemia and Vascular Diseases
    Ming Jin, Fan Yang, Irene Yang, Ying Yin, Jin Jun Luo, Hong Wang, Xiao-Feng Yang
    Front Biosci. 2012 January 1; 17: 656–669.

    The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
    Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH.
    Nat Rev Gastroenterol Hepatol. 2010 May;7(5):251-64. doi: 10.1038/nrgastro.2010.41. Epub 2010 Apr 6.

    Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity.
    Payne AN, Chassard C, Lacroix C.
    Obes Rev. 2012 Sep;13(9):799-809. doi: 10.1111/j.1467-789X.2012.01009.x. Epub 2012 Jun 11.

    Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?
    Richard J. Johnson, Santos E. Perez-Pozo, Yuri Y. Sautin, Jacek Manitius, Laura Gabriela Sanchez-Lozada, Daniel I. Feig, Mohamed Shafiu, Mark Segal, Richard J. Glassock, Michiko Shimada, Carlos Roncal, and Takahiko Nakagawa
    Endocr Rev. 2009 February; 30(1): 96–116.
    Published online 2009 January 16. doi: 10.1210/er.2008-0033

    Dietary components in the development of leptin resistance.
    Vasselli JR, Scarpace PJ, Harris RB, Banks WA.
    Adv Nutr. 2013 Mar 1;4(2):164-75. doi: 10.3945/an.112.003152.

    Mechanisms for the acute effect of fructose on postprandial lipemia.
    Chong MF, Fielding BA, Frayn KN.
    Am J Clin Nutr. 2007 Jun;85(6):1511-20.

    Is the metabolic syndrome caused by a high fructose, and relatively low fat, low cholesterol diet?
    Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.
    Seneff S, Wainwright G, Mascitelli L.
    Arch Med Sci. 2011 Feb;7(1):8-20. doi: 10.5114/aoms.2011.20598. Epub 2011 Mar 8.

    Regulation of low-density lipoprotein subfractions by carbohydrates.
    Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):381-5. doi: 10.1097/MCO.0b013e3283545a6d.
    Gerber PA, Berneis K.
    Source
    Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.

    Current concepts and management approaches in nonalcoholic fatty liver disease.
    Attar BM, Van Thiel DH.
    ScientificWorldJournal. 2013;2013:481893. doi: 10.1155/2013/481893. Epub 2013 Mar 20.
    Source
    Division of Gastroenterology and Hepatology, Cook County Health and Hospitals System, John H. Stroger Hospital of Cook County, Rush University Medical Center, 1901 West Harrison Street, Administration Building, Suite 1450, Chicago, IL 60612, USA. bashar attar@rush.edu

    Fructose, weight gain, and the insulin resistance syndrome
    Sharon S Elliott, Nancy L Keim, Judith S Stern, Karen Teff, and Peter J Havel
    Am J Clin Nutr 2002;76:911–22

    Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    Mark J. Dekker, Qiaozhu Su, Chris Baker, Angela C. Rutledge, and Khosrow Adeli
    Am J Physiol Endocrinol Metab 299: E685–E694, 2010.
    Molecular Structure and Function, Research Institute, The Hospital for Sick Children; and Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    Pathophysiology of human visceral obesity: an update
    Tchernof A, Després JP.Physiol Rev. 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011.93(1):359-404. doi: 10.1152/physrev.00033.2011.

    Carbohydrate intake and nonalcoholic fatty liver disease.
    Neuschwander-Tetri BA.
    Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):446-52. doi: 10.1097/MCO.0b013e328361c4d1.

    The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat.
    Thomas EL, Parkinson JR, Frost GS, Goldstone AP, Doré CJ, McCarthy JP, Collins AL, Fitzpatrick JA, Durighel G, Taylor-Robinson SD, Bell JD.
    Obesity (Silver Spring). 2012 Jan;20(1):76-87. doi: 10.1038/oby.2011.142. Epub 2011 Jun 9.
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.

    Excess body fat in obese and normal-weight subjects.
    Thomas EL, Frost G, Taylor-Robinson SD, Bell JD.
    Nutr Res Rev. 2012 Jun;25(1):150-61. doi: 10.1017/S0954422412000054. Epub 2012 May 25.
    Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. louise.thomas@csc.mrc.ac.uk

    Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity.
    Payne AN, Chassard C, Lacroix C.
    Obes Rev. 2012 Sep;13(9):799-809. doi: 10.1111/j.1467-789X.2012.01009.x. Epub 2012 Jun 11.
    Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, Zurich, Switzerland
    Basaranoglu M, Basaranoglu G, Sabuncu T, Sentürk H.

    Fructose as a key player in the development of fatty liver disease.
    World J Gastroenterol. 2013 Feb 28;19(8):1166-72. doi: 10.3748/wjg.v19.i8.1166.

    Impact of obesity on total and cardiovascular mortality–fat or fiction?
    Nat Rev Cardiol. 2011 Apr;8(4):233-7. doi: 10.1038/nrcardio.2010.209. Epub 2011 Jan 25.
    Cepeda-Valery B, Pressman GS, Figueredo VM, Romero-Corral A.

    Way back for fructose and liver metabolism: Bench side to molecular insights
    Alba Rebollo, Núria Roglans, Marta Alegret, and Juan C Laguna
    World J Gastroenterol. 2012 December 7; 18(45): 6552–6559.
    Published online 2012 December 7. doi: 10.3748/wjg.v18.i45.6552
    PMCID: PMC3516224

    Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
    Diabetes. 2002 Feb;51(2):469-78.
    Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD.
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA. masakazu.shiota@mcmail.vanderbilt.edu

    Fructose: a key factor in the development of metabolic syndrome and hypertension.
    Nutr Metab. 2013;2013:682673. doi: 10.1155/2013/682673. Epub 2013 May 25.
    Khitan Z, Kim DH.
    Marshall University’s Joan C. Edwards School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701-3655, USA ; Department of Medicine, Marshall University Joan Edwards School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701-3655, USA.

    Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial.
    Diabetes Care. 2013 Jan;36(1):150-6. doi: 10.2337/dc12-0540. Epub 2012 Aug 28.
    Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K.
    Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.

    Fructose and risk of cardiometabolic disease.
    Curr Atheroscler Rep. 2012 Dec;14(6):570-8. doi: 10.1007/s11883-012-0276-6.
    Bray GA.
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA. brayga@pbrc.edu

    Posted in References.

    2 Comments

      • Thank you for your comments and your paper ‘The High-Cholesterol Paradox’ which makes for excellent reading!

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